Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity

Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity

The therapeutic potential of botulinum neurotoxin type A (BoNT/A) has recently been widely recognized. BoNT/A acts to silence synaptic transmission via specific proteolytic cleavage of an essential neuronal protein, SNAP25. The advantages of BoNT/A-mediated synaptic silencing include very long durat...

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Bibliographic Details
Main Authors: Bazbek Davletov, Giampietro Schiavo, Dhevahi Niranjan, Ornella Rossetto, Michael H. Hastings, Marco Pirazzini, Matteo Caleo, Enrico Ferrari, Elizabeth S. Maywood, Laura Restani
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Toxins
Subjects:
botulinum neurotoxin
nervous system
protein engineering
synapse
SNAREs
BOTOX
BITOX
Online Access:http://www.mdpi.com/2072-6651/3/4/345/

Internet

http://www.mdpi.com/2072-6651/3/4/345/

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