Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues

The synthesis of novel peptide conjugates of N-substituted-tetrahydro-γ-carbolines has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry. The effect of obtained γ-carboline–peptide conjugates on the rat liver mitochondria was evaluated. It was f...

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Bibliographic Details
Main Authors: Nadezhda V. Sokolova, Valentine G. Nenajdenko, Vladimir B. Sokolov, Daria V. Vinogradova, Elena F. Shevtsova, Ludmila G. Dubova, Sergey O. Bachurin
Format: Article
Language:English
Published: Beilstein-Institut 2014-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
mitochondrial membrane potential
mitochondrial permeability transition
multicomponent
peptides
tetrahydro-γ-carbolines
Ugi multicomponent reaction
Online Access:https://doi.org/10.3762/bjoc.10.13

Internet

https://doi.org/10.3762/bjoc.10.13

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