Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues
The synthesis of novel peptide conjugates of N-substituted-tetrahydro-γ-carbolines has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry. The effect of obtained γ-carboline–peptide conjugates on the rat liver mitochondria was evaluated. It was f...
Main Authors: | Nadezhda V. Sokolova, Valentine G. Nenajdenko, Vladimir B. Sokolov, Daria V. Vinogradova, Elena F. Shevtsova, Ludmila G. Dubova, Sergey O. Bachurin |
---|---|
Format: | Article |
Language: | English |
Published: |
Beilstein-Institut
2014-01-01
|
Series: | Beilstein Journal of Organic Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.3762/bjoc.10.13 |
Similar Items
-
The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure
by: Francesco Airaghi, et al.
Published: (2013-01-01) -
Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives
by: Giordano Lesma, et al.
Published: (2014-06-01) -
Synthesis of gbs-carbolines and their tetrahydro derivatives
by: Zarrinmayeh, Hamideh
Published: (2011) -
Mild and Efficient Winterfeldt Oxidation of 1,2,3,4-Tetrahydro-γ-carbolines for the Synthesis of Dihydropyrrolo[3,2-b]-quinolones and Pyrrolo[3,2-b]quinolones
by: Rong Sheng, et al.
Published: (2012-01-01) -
Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines
by: Amit Kumar, et al.
Published: (2013-10-01)