HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1.

Upon recognition of viral components by pattern recognition receptors, such as the toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like helicases, cells are activated to produce type I interferon (IFN) and proinflammatory cytokines. These pathways are tightly regulated by the h...

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Bibliographic Details
Main Authors: Yanni Chen, Junbo Chen, Hui Wang, Jingjing Shi, Kailang Wu, Shi Liu, Yingle Liu, Jianguo Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3635988?pdf=render