Age and Origin of the Founder Antithrombin Budapest 3 (p.Leu131Phe) Mutation; Its High Prevalence in the Roma Population and Its Association With Cardiovascular Diseases

Age and Origin of the Founder Antithrombin Budapest 3 (p.Leu131Phe) Mutation; Its High Prevalence in the Roma Population and Its Association With Cardiovascular Diseases

Background: Antithrombin (AT) is one of the most important regulator of hemostasis. AT Budapest 3 (ATBp3) is a prevalent type II heparin-binding site (IIHBS) deficiency due to founder effect. Thrombosis is a complex disease including arterial (ATE) and venous thrombotic events (VTE) and the Roma pop...

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Bibliographic Details
Main Authors: Zsuzsanna Bereczky, Réka Gindele, Szilvia Fiatal, Marianna Speker, Tünde Miklós, László Balogh, Zoltán Mezei, Zsuzsanna Szabó, Róza Ádány
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
antithrombin deficiency
antithrombin Budapest 3
founder effect
Roma population
cardiovascular disease
thrombosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.617711/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2020.617711/full

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