Synchronous LC-MS/MS determination of pantoprazole and amitriptyline in rabbit plasma: application to comparative in vivo pharmacokinetic study of novel formulated effervescent granules with its marketed tablet dosage form

Synchronous LC-MS/MS determination of pantoprazole and amitriptyline in rabbit plasma: application to comparative in vivo pharmacokinetic study of novel formulated effervescent granules with its marketed tablet dosage form

In the present study the bioavailability and pharmacokinetics properties of pantoprazole (proton pump inhibitor)/amitriptyline (tricyclic antidepressant) in novel formulated effervescent granules was estimated in rabbit plasma using a validated, selective and rapid LC-MS/MS method. Separation and de...

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Bibliographic Details
Main Authors: Asmaa A. El Zaher, Ehab F. El Kady, Hussein M. EL Messiry, Hind E. El Ghwas, Ola M. El Houssini
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Heliyon
Subjects:
LC-MS/MS
Pantoprazole
Amitriptyline
Effervescent granules
Bioanalysis
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021018557

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http://www.sciencedirect.com/science/article/pii/S2405844021018557

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