Using practice effects for targeted trials or sub-group analysis in Alzheimer's disease: How practice effects predict change over time.

OBJECTIVE:To describe the presence of practice effects in persons with Alzheimer disease (AD) or mild cognitive impairment (MCI) and to evaluate how practice effects affect cognitive progression and the outcome of clinical trials. METHODS:Using data from a meta-database consisting of 18 studies incl...

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Bibliographic Details
Main Authors: Guoqiao Wang, Richard E Kennedy, Terry E Goldberg, Mackenzie E Fowler, Gary R Cutter, Lon S Schneider
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228064