Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse

Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse

We generated an NOD/Shi-scid-IL2Rγnull (NOG) mouse deficient for the Fcer1g and Fcgr2b genes (NOG-FcγR−/− mice), in which monocytes/macrophages do not express activating (FcγRI, III, and IV) or inhibitory (FcγRIIB) Fcγ receptors. Antibody-dependent cellular cytotoxicity (ADCC) by innate immune cells...

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Bibliographic Details
Main Authors: Ikumi Katano, Ryoji Ito, Kenji Kawai, Takeshi Takahashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
humanized mice
NK cell
FcγR
ADCC
mouse innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.532684/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.532684/full

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