Evaluation of two xenobiotic reductases from Pseudomonas putida for their suitability for magnetic nanoparticle‐directed enzyme prodrug therapy as a novel approach to cancer treatment
Abstract Directed enzyme prodrug therapy (DEPT) is a cancer chemotherapy strategy in which bacterial enzymes are delivered to a cancer site before prodrug administration, resulting in prodrug activation at the cancer site and more localized treatment. A major limitation to DEPT is the poor effective...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2020-10-01
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Series: | MicrobiologyOpen |
Online Access: | https://doi.org/10.1002/mbo3.1110 |