decompTumor2Sig: identification of mutational signatures active in individual tumors

decompTumor2Sig: identification of mutational signatures active in individual tumors

Abstract Background The somatic mutations found in a tumor have in most cases been caused by multiple mutational processes such as those related to extrinsic carcinogens like cigarette smoke, and those related to intrinsic processes like age-related spontaneous deamination of 5-methylcytosine. The e...

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Bibliographic Details
Main Authors: Sandra Krüger, Rosario M. Piro
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Bioinformatics
Subjects:
Somatic mutations
Mutational processes
Mutational signatures
Signature refitting
Decomposition of tumor genomes
Online Access:http://link.springer.com/article/10.1186/s12859-019-2688-6

Internet

http://link.springer.com/article/10.1186/s12859-019-2688-6

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