TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

The PI3K/AKT signalling pathway regulates cancer metabolism. Here, the authors show a reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis.

Bibliographic Details
Main Authors: Jie Cheng, Yan Huang, Xiaohui Zhang, Yue Yu, Shumin Wu, Jing Jiao, Linh Tran, Wanru Zhang, Ran Liu, Liuzhen Zhang, Mei Wang, Mengyao Wang, Wenyu Yan, Yilin Wu, Fangtao Chi, Peng Jiang, Xinxiang Zhang, Hong Wu
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15819-3

Internet

https://doi.org/10.1038/s41467-020-15819-3

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