Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis

Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis

Liver ischemia-reperfusion injury (IRI) is a common clinical event with high morbidity in patients undergoing complex liver surgery or having abdominal trauma. Inflammatory and oxidative stress responses are the main contributing factors in liver IRI. The iridoid glucoside aucubin (AU) has good anti...

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Bibliographic Details
Main Authors: Shilong Zhang, Zanjie Feng, Weidong Gao, Yuling Duan, Guoxin Fan, Xin Geng, Bo Wu, Kai Li, Kangwei Liu, Cijun Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
ischemia-reperfusion
liver
inflammation
oxidative stress
apoptosis
aucubin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.544124/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.544124/full

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