RNA-Seq Analysis of Cisplatin and The Monofunctional Platinum(II) Complex, Phenanthriplatin, in A549 Non-Small Cell Lung Cancer and IMR90 Lung Fibroblast Cell Lines

RNA-Seq Analysis of Cisplatin and The Monofunctional Platinum(II) Complex, Phenanthriplatin, in A549 Non-Small Cell Lung Cancer and IMR90 Lung Fibroblast Cell Lines

Phenanthriplatin is a new monofunctional platinum(II) complex that binds only one strand of DNA and acts by blocking gene transcription, but its effect on gene regulation has not been characterized relative to the traditional platinum-based complex, cisplatin. A549 non-small cell lung cancer and IMR...

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Bibliographic Details
Main Authors: Jerry D. Monroe, Satya A. Moolani, Elvin N. Irihamye, Joshua S. Speed, Yann Gibert, Michael E. Smith
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
next generation sequencing
cancer
monofunctional platinum(II) complex
pathway analysis
cisplatin
Online Access:https://www.mdpi.com/2073-4409/9/12/2637

Internet

https://www.mdpi.com/2073-4409/9/12/2637

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