Untargeted metabolomics reveals dose-response characteristics for effect of rhubarb in a rat model of cholestasis

Untargeted metabolomics reveals dose-response characteristics for effect of rhubarb in a rat model of cholestasis

Cholestasis is a serious manifestation of liver diseases with limited therapies. Rhubarb, a widely used herbal medicine, has been frequently used at a relatively large dose for treating cholestasis. However, whether large doses are optimal and the therapeutic mechanism remain unclear. To explore the...

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Bibliographic Details
Main Authors: Cong-En eZhang, Ming eNiu, Rui-yu eLi, Wu-Wen eFeng, Xiao eMa, Qin eDong, Zhi-jie eMa, Guang-Quan eLi, Ya-Kun eMeng, Ya eWang, Ping eYin, Lan-Zhi eHe, Yu-Meng eLi, Peng eTan, Yan-ling eZhao, Jia-Bo eWang, Xiao-ping eDong, Xiao-he eXiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Cholestasis
Metabolomics
pathway analysis
dose response
Rhubarb
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00085/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00085/full

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