Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines

Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines

We report the chemical synthesis of a new photoactivatable cholesterol analog 7,7-azocholestanol (AC) and its linoleate ester (ACL). We also examined the biochemical properties of the sterol and its ester by employing several different mutant Chinese hamster ovary (CHO) cell lines with defined abnor...

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Bibliographic Details
Main Authors: Jonathan C. Cruz, Matthew Thomas, Edmund Wong, Nobutaka Ohgami, Shigeki Sugii, Thomas Curphey, Catherine C.Y. Chang, Ta-Yuan Chang
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Journal of Lipid Research
Subjects:
UV cross-linking
photoactivatable cholesterol analog
cholesterol-protein interaction
cholesterol mutants
Niemann-Pick type C disease
acyl-coenzyme A:cholesterol acyltransferase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520300675

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