Muscone Ameliorates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κb Ligand-Induced Osteoclastogenesis by Suppressing TNF Receptor–Associated Factor 6-Mediated Signaling Pathways

Muscone Ameliorates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κb Ligand-Induced Osteoclastogenesis by Suppressing TNF Receptor–Associated Factor 6-Mediated Signaling Pathways

Postmenopausal osteoporosis is caused by the deficiency of estrogen, which breaks bone homeostasis and induces levels of pro-inflammatory cytokines. Muscone is a potent anti-inflammatory agent and is used to treat bone fracture in traditional Chinese medicine. However, its anti-osteoclastogenic effe...

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Bibliographic Details
Main Authors: Xiao Zhai, Zijun Yan, Jian Zhao, Kai Chen, Yilin Yang, Mengxi Cai, Chen He, Chunyou Huang, Bo Li, Mingyuan Yang, Xiaoyi Zhou, Yingchuan Zhao, Xiaozhao Wei, Yushu Bai, Ming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
muscone
postmenopausal osteoporosis
osteoclasts
RANK
TRAF6
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00348/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00348/full

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