Sub-nanowatt resolution direct calorimetry for probing real-time metabolic activity of individual C. elegans worms

Calorimetry is widely used for metabolic studies, but measurements of single cells and small organisms are limited by the sensitivity of current techniques. Here the authors develop a sensitive platform for performing time-resolved metabolic measurements of single C. elegans worms from larval to adu...

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Bibliographic Details
Main Authors: Sunghoon Hur, Rohith Mittapally, Swathi Yadlapalli, Pramod Reddy, Edgar Meyhofer
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16690-y