Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway

Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway

Both hydrogen peroxide (H2O2, H) and ischemia/reperfusion (I/R) can damage cardiomyocytes, which was inhibited by propofol (P). The present research was designed to examine whether propofol can reduce myocardial I/R injury by activating protein kinase C (PKC)/nuclear factor erythroid-2-related facto...

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Bibliographic Details
Main Authors: Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
propofol
heart
ischemia reperfusion
protein kinase C
nuclear factor erythroid-2- related factor
heme oxygenase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.655726/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.655726/full

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