Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy

Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy

Familial dilated cardiomyopathy (DCM) is mostly caused by mutations in genes encoding cytoskeletal and sarcomeric proteins. In the pediatric population, DCM is the predominant type of primitive myocardial disease. A severe form of DCM is associated with mutations in the DMD gene encoding dystrophin,...

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Bibliographic Details
Main Authors: Josè Manuel Pioner, Alessandra Fornaro, Raffaele Coppini, Nicole Ceschia, Leonardo Sacconi, Maria Alice Donati, Silvia Favilli, Corrado Poggesi, Iacopo Olivotto, Cecilia Ferrantini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
dilated cardiomyopathy (DCM)
duchenne muscular dystrophy (DMD)
dystrophin (DMD)
hiPSC-cardiomyocyte
stem cell models
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00368/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00368/full

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