c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.

c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.

Cellular FLIP (c-FLIP) is an enzymatically inactive paralogue of caspase-8 and as such can block death receptor-induced apoptosis. However, independent of death receptors, c-FLIP-Long (c-FLIPL) can heterodimerize with and activate caspase-8. This is critical for promoting the growth and survival of...

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Bibliographic Details
Main Authors: Iwona A Buskiewicz, Andreas Koenig, Brian Roberts, Jennifer Russell, Cuixia Shi, Sun-Hwa Lee, Jae U Jung, Sally A Huber, Ralph C Budd
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4015977?pdf=render

Internet

http://europepmc.org/articles/PMC4015977?pdf=render

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