Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice

Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice

Islet transplantation can restore glycemic control in patients with type 1 diabetes. Using this procedure, the early stages of engraftment are often crucial to long-term islet function, and outcomes are not always successful. Numerous studies have shown that mesenchymal stem cells (MSCs) facilitate...

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Bibliographic Details
Main Authors: Suzanne Bertera, Michael F. Knoll, Carmela Knoll, Hidetaka Hara, Erin A. Kimbrel, Nickolas A. Kouris, Robert Lanza, Brett E. Philips, Yesica Garciafigueroa, Nick Giannoukakis, David K. C. Cooper, Massimo Trucco, Rita Bottino
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Medicine
Subjects:
hemangioblast-derived mesenchymal cell
human embryonic stem cell
mesenchymal stem cell
type 1 diabetes
islet transplantation
minimal islet mass model
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.660877/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.660877/full

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