Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor.

Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor.

Human infection caused by the avian influenza A H7N9 virus has a case-fatality rate of over 30%. Systematic study of the pathogenesis of avian H7N9 isolate and effective therapeutic strategies are needed.BALB/c mice were inoculated intranasally with an H7N9 virus isolated from a chicken in a wet mar...

Full description

Bibliographic Details
Main Authors: Can Li, Chuangen Li, Anna J X Zhang, Kelvin K W To, Andrew C Y Lee, Houshun Zhu, Hazel W L Wu, Jasper F W Chan, Honglin Chen, Ivan F N Hung, Lanjuan Li, Kwok-Yung Yuen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4169509?pdf=render

Internet

http://europepmc.org/articles/PMC4169509?pdf=render

Similar Items