Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with an increased risk of schizophrenia, obesity, Crohn’s disease, and reduced blood Mn. Here...

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Bibliographic Details
Main Authors: Laxmi Sunuwar, Azra Frkatović, Sodbo Sharapov, Qinchuan Wang, Heather M. Neu, Xinqun Wu, Talin Haritunians, Fengyi Wan, Sarah Michel, Shaoguang Wu, Mark Donowitz, Dermot McGovern, Gordan Lauc, Cynthia Sears, Joanna Melia
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-10-01
Series:JCI Insight
Subjects:
Gastroenterology
Genetics
Online Access:https://doi.org/10.1172/jci.insight.140978

Internet

https://doi.org/10.1172/jci.insight.140978

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