A subset of microRNAs in the Dlk1‐Dio3 cluster regulates age‐associated muscle atrophy by targeting Atrogin‐1

A subset of microRNAs in the Dlk1‐Dio3 cluster regulates age‐associated muscle atrophy by targeting Atrogin‐1

Abstract Background The microRNAs (miRNAs) down‐regulated in aged mouse skeletal muscle were mainly clustered within the delta‐like homologue 1 and the type III iodothyronine deiodinase (Dlk1‐Dio3) genomic region. Although clustered miRNAs are coexpressed and regulate multiple targets in a specific...

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Bibliographic Details
Main Authors: Yeo Jin Shin, Eun‐Soo Kwon, Seung‐Min Lee, Seon‐Kyu Kim, Kyung‐Won Min, Jae‐Young Lim, Bora Lee, Jae Sook Kang, Ju Yeon Kwak, Young Hoon Son, Jeong Yi Choi, Yong Ryul Yang, Seokho Kim, Yeon‐Soo Kim, Hak C. Jang, Yousin Suh, Je‐Hyun Yoon, Kwang‐Pyo Lee, Ki‐Sun Kwon
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Dlk1‐Dio3 miRNA cluster
Muscle aging
Sarcopenia
Atrophy
Cachexia
Atrogin‐1
Online Access:https://doi.org/10.1002/jcsm.12578

Internet

https://doi.org/10.1002/jcsm.12578

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