Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of <i>Escherichia coli</i>

Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of <i>Escherichia coli</i>

The drug/proton antiporter AcrB, engine of the major efflux pump AcrAB(Z)-TolC of <i>Escherichia coli</i> and other bacteria, is characterized by its impressive ability to transport chemically diverse compounds, conferring a multi-drug resistance (MDR) phenotype. Although hundreds of sma...

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Bibliographic Details
Main Authors: Alessio Atzori, Giuliano Malloci, Francesca Cardamone, Andrea Bosin, Attilio Vittorio Vargiu, Paolo Ruggerone
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
antibiotic resistance
gram-negative bacteria
resistance nodulation-cell division transporters
acrb
molecular docking
molecular dynamics simulations
binding free energy calculations
Online Access:https://www.mdpi.com/1422-0067/21/3/860

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https://www.mdpi.com/1422-0067/21/3/860

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