Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism.

Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism.

Diabetes and associated metabolic conditions have reached pandemic proportions worldwide, and there is a clear unmet medical need for new therapies that are both effective and safe. FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones. Both have potent effect...

Full description

Bibliographic Details
Main Authors: Hongfei Ge, Helene Baribault, Steven Vonderfecht, Bryan Lemon, Jennifer Weiszmann, Jonitha Gardner, Ki Jeong Lee, Jamila Gupte, Paramita Mookherjee, Minghan Wang, Jackie Sheng, Xinle Wu, Yang Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3311646?pdf=render

Internet

http://europepmc.org/articles/PMC3311646?pdf=render

Similar Items