Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin

Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin

The concept that hepatic cholesterol synthesis regulates hepatocyte assembly and secretion of apoB-containing lipoproteins remains controversial. The present study was carried out in HepG2 cells to examine the regulation of apoB secretion by the HMG-CoA reductase inhibitor atorvastatin. ApoB accumul...

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Bibliographic Details
Main Authors: Lisa J. Wilcox, P. Hugh R. Barrett, Murray W. Huff
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Journal of Lipid Research
Subjects:
HMG-CoA reductase inhibitor
apoB
HepG2 cells
cholesterol synthesis
atorvastatin
simvastatin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335124

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http://www.sciencedirect.com/science/article/pii/S0022227520335124

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