A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

Mouse models of gastroesophageal junction (GEJ) cancer strive to recapitulate the intratumoral heterogeneity and cellular crosstalk within patient tumors to improve clinical translation. GEJ cancers remain a therapeutic challenge due to the lack of a reliable mouse model for preclinical drug testing...

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Bibliographic Details
Main Authors: Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
Format: Article
Language:English
Published: The Company of Biologists 2019-12-01
Series:Disease Models & Mechanisms
Subjects:
patient-derived orthotopic xenograft mouse model
esophageal adenocarcinoma
gastroesophageal junction cancer
mouse models
microenvironment
Online Access:http://dmm.biologists.org/content/12/12/dmm041004

Internet

http://dmm.biologists.org/content/12/12/dmm041004

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