An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelinati...

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Bibliographic Details
Main Authors: Michael B. Keough, James A. Rogers, Ping Zhang, Samuel K. Jensen, Erin L. Stephenson, Tieyu Chen, Mitchel G. Hurlbert, Lorraine W. Lau, Khalil S. Rawji, Jason R. Plemel, Marcus Koch, Chang-Chun Ling, V. Wee Yong
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11312

Internet

https://doi.org/10.1038/ncomms11312

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