An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelinati...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11312 |