Protein Tyrosine Nitration and Thiol Oxidation by Peroxynitrite—Strategies to Prevent These Oxidative Modifications

Protein Tyrosine Nitration and Thiol Oxidation by Peroxynitrite—Strategies to Prevent These Oxidative Modifications

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-...

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Bibliographic Details
Main Authors: Thomas Münzel, Serge Bottari, Tadashi Tanabe, Masayuki Wada, Alexandra Megner, Patrick Schmidt, Sebastian Steven, Matthias Oelze, Stefan Schildknecht, Markus Bachschmid, Steffen Daub, Andreas Daiber, Volker Ullrich
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
nitric oxide
superoxide
peroxynitrite
protein tyrosine nitration
thiol oxidation
peroxynitrite scavengers
prostacyclin synthase
Online Access:http://www.mdpi.com/1422-0067/14/4/7542

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http://www.mdpi.com/1422-0067/14/4/7542

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