Titanium-mediated reductive cross-coupling reactions of imines with terminal alkynes: An efficient route for the synthesis of stereodefined allylic amines

Titanium-mediated reductive cross-coupling reactions of imines with terminal alkynes: An efficient route for the synthesis of stereodefined allylic amines

Low-valency titanium species, generated in situ by using Ti(OiPr)4/2 c-C5H9MgCl reagent, react with imines to give a titanium-imine complex that can couple with terminal alkynes to provide azatitanacyclopentenes with excellent regioselectivity. Stereodefined allylic amines are obtained in good yield...

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Bibliographic Details
Main Authors: Kebin Mao, Guoqin Fan, Yuanhong Liu, Shi Li, Xu You, Dan Liu
Format: Article
Language:English
Published: Beilstein-Institut 2013-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
allylic amine
azatitanacyclopentene
reductive cross-coupling
regioselectivity
terminal alkyne
titanium-imine complex
Online Access:https://doi.org/10.3762/bjoc.9.69

Internet

https://doi.org/10.3762/bjoc.9.69

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