Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition.

Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition.

Nuclear migration is regulated by the LIS1 protein, which is the regulatory subunit of platelet activating factor (PAF) acetyl-hydrolase, an enzyme complex that inactivates the lipid mediator PAF. Among other functions, PAF modulates cell proliferation, but its effects upon mechanisms of the cell cy...

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Bibliographic Details
Main Authors: Lucianne Fragel-Madeira, Tamara Meletti, Rafael M Mariante, Robson Q Monteiro, Marcelo Einicker-Lamas, Robson R Bernardo, Angela H Lopes, Rafael Linden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3029264?pdf=render

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http://europepmc.org/articles/PMC3029264?pdf=render

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