Coordinate to guard: crosstalk of phosphorylation, sumoylation and ubiquitylation in DNA damage response

Coordinate to guard: crosstalk of phosphorylation, sumoylation and ubiquitylation in DNA damage response

Small ubiquitin-like modifier-1/2/3 (SUMO-1/2/3) and ubiquitin share similar structure and utilize analogous machinery for protein lysine conjugation. Although sumoylation and ubiquitylation have distinct functions, they are often tightly associated with each other to fine-tune protein fate in trans...

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Bibliographic Details
Main Authors: Ching-Ying eKuo, Christine eShieh, Fei eCai, David Kong Ann
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Oncology
Subjects:
Phosphorylation
Sumoylation
ubiquitylation
DNA damage response
ATM
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00061/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00061/full

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