The β-<i>N</i>-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering

The β-<i>N</i>-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering

<i>N</i>-Acetylhexosamine oligosaccharides terminated with GalNAc act as selective ligands of galectin-3, a biomedically important human lectin. Their synthesis can be accomplished by &#946;-<i>N</i>-acetylhexosaminidases (EC 3.2.1.52). Advantageously, these enzymes toler...

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Bibliographic Details
Main Authors: Pavla Bojarová, Natalia Kulik, Michaela Hovorková, Kristýna Slámová, Helena Pelantová, Vladimír Křen
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
β-<i>N</i>-acetylhexosaminidase
galectin-3
molecular modeling
site-directed mutagenesis
solvent
substrate specificity
transglycosidase
Online Access:https://www.mdpi.com/1420-3049/24/3/599

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https://www.mdpi.com/1420-3049/24/3/599

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