Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis

Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis

The IL-23/T helper 17 (Th17) axis plays an important role in joint inflammation in ankylosing spondylitis (AS). Conventional CD4+ Th17 cells are a major source of IL-17A. IL-22 is another cytokine implicated in AS pathophysiology and is produced by Th17 and Th22 cells. In this study, we aimed to ana...

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Bibliographic Details
Main Authors: Éric Toussirot, Caroline Laheurte, Béatrice Gaugler, Damien Gabriel, Philippe Saas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
ankylosing spondylitis
IL-17A
IL-22
mucosal-associated invariant T cells
mucosal immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01610/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01610/full

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