Uroplakin Ib Gene Transcription in Urothelial Tumor Cells Is Regulated by CpG Methylation

Uroplakin Ib is a structural protein on the surface of urothelial cells. Levels of uroplakin Ib mRNA are dramatically reduced or absent in many transitional cell carcinomas, but the molecular mechanisms responsible remain undetermined. Previously, we showed that loss of uroplakin Ib expression corr...

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Bibliographic Details
Main Authors: Prue Cowled, Irene Kanter, Lefta Leonardos, Paul Jackson
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Sp1
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800466