3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation

3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation

Herein we report the design, synthesis, computational, and experimental evaluation of the antimicrobial activity of fourteen new 3-amino-5-(indol-3-yl) methylene-4-oxo-2-thioxothiazolidine derivatives. The structures were designed, and their antimicrobial activity and toxicity were predicted in sili...

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Bibliographic Details
Main Authors: Volodymyr Horishny, Victor Kartsev, Vasyl Matiychuk, Athina Geronikaki, Petrou Anthi, Pavel Pogodin, Vladimir Poroikov, Marija Ivanov, Marina Kostic, Marina D. Soković, Phaedra Eleftheriou
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceuticals
Subjects:
indole
thioxothiazolidine
antibacterial activity
antifungal activity
computer-aided prediction
docking
Online Access:https://www.mdpi.com/1424-8247/13/9/229

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https://www.mdpi.com/1424-8247/13/9/229

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