A novel crosslinked type of advanced glycation end-product derived from lactaldehyde

Glycation of amino or guanidino groups of proteins with glucose and glucose-derived reactive aldehydes, such as α-hydroxyaldehydes, leads to accumulation of advanced glycation end-products (AGEs) in the body, resulting in diabetic complications and age-related pathology. Although molecular structure...

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Bibliographic Details
Main Authors: Tomoaki Shigeta, Kazumi Sasamoto, Tetsuro Yamamoto
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020321800