Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

Islet transplantation is a feasible approach to treat type I diabetes, however inflammation and poor vascularisation impair long-term engraftment. Here the authors show that incorporating human amniotic epithelial cells into islet organoids improves engraftment and function of organoids, through enh...

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Bibliographic Details
Main Authors: Fanny Lebreton, Vanessa Lavallard, Kevin Bellofatto, Romain Bonnet, Charles H. Wassmer, Lisa Perez, Vakhtang Kalandadze, Antonia Follenzi, Michel Boulvain, Julie Kerr-Conte, David J. Goodman, Domenico Bosco, Thierry Berney, Ekaterine Berishvili
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12472-3

Internet

https://doi.org/10.1038/s41467-019-12472-3

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