Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro

Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro

Spines are small protrusions arising from dendrites that receive most excitatory synaptic input in the brain. Dendritic spines represent dynamic structures that undergo activity-dependent adaptations, for example, during synaptic plasticity. Alterations of spine morphology, changes of spine type rat...

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Bibliographic Details
Main Authors: Anja eBlanque, Daniele eRepetto, Astrid eRohlmann, Johannes eBrockhaus, Kerstin eDuning, Hermann ePavenstädt, Ilka eWolff, Markus eMissler
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Neuroanatomy
Subjects:
Cognition
cell culture
plasticity
synapse function
Electron microscopy
Golgi-staining
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00013/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00013/full

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