Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

Abstract Focal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in FCD is associated with inaccurate localization of the EZ. Hence, identifying novel epileptogenic markers to aid in the localization of EZ in pa...

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Bibliographic Details
Main Authors: Arpna Srivastava, Krishan Kumar, Jyotirmoy Banerjee, Manjari Tripathi, Vivek Dubey, Devina Sharma, Nitin Yadav, M. C. Sharma, Sanjeev Lalwani, Ramesh Doddamani, P. Sarat Chandra, Aparna Banerjee Dixit
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
Focal cortical dysplasia
Drug-resistant epilepsy
High spiking region
Low spiking region
RNA sequencing
Differential expression
Online Access:https://doi.org/10.1186/s13041-021-00832-4

Internet

https://doi.org/10.1186/s13041-021-00832-4

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