Detecting novel genetic variants associated with isoniazid-resistant Mycobacterium tuberculosis.

Detecting novel genetic variants associated with isoniazid-resistant Mycobacterium tuberculosis.

Isoniazid (INH) is a highly effective antibiotic central for the treatment of Mycobacterium tuberculosis (MTB). INH-resistant MTB clinical isolates are frequently mutated in the katG gene and the inhA promoter region, but 10 to 37% of INH-resistant clinical isolates have no detectable alterations in...

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Bibliographic Details
Main Authors: Sandhya Shekar, Zhen Xuan Yeo, Joshua C L Wong, Maurice K L Chan, Danny C T Ong, Pumipat Tongyoo, Sin-Yew Wong, Ann S G Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4099304?pdf=render

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http://europepmc.org/articles/PMC4099304?pdf=render

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