p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition

p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition

Abstract Background We reported previously that phenethyl isothiocyanate (PEITC), a dietary compound, can reactivate p53R175H mutant in vitro and in SK-BR-3 (p53R175H) breast xenograft model resulting in tumor inhibition. Because of the diversity of human cancers with p53 mutations, these findings r...

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Bibliographic Details
Main Authors: Monika Aggarwal, Rahul Saxena, Nasir Asif, Elizabeth Sinclair, Judy Tan, Idalia Cruz, Deborah Berry, Bhaskar Kallakury, Quynhchi Pham, Thomas T. Y. Wang, Fung-Lung Chung
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Tumor suppressor protein
p53 mutation
Reactivation
Phenethyl isothiocyanate
Prostate cancer
Chemoprevention
Online Access:http://link.springer.com/article/10.1186/s13046-019-1267-z

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http://link.springer.com/article/10.1186/s13046-019-1267-z

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