Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization

Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization

Abstract Background Medulloblastoma (MB), the most common pediatric brain cancer, presents with a poor prognosis in a subset of patients with high risk disease, or at recurrence, where current therapies are ineffective. Cord blood (CB) natural killer (NK) cells may be promising off-the-shelf effecto...

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Bibliographic Details
Main Authors: Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin Pei, Eric S. Yvon, Eugene I. Hwang, Catherine M. Bollard, Javad Nazarian, Conrad Russell Y. Cruz
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Translational Medicine
Subjects:
TGFβ
NK cells
Medulloblastoma
Adoptive immunotherapy
Online Access:http://link.springer.com/article/10.1186/s12967-019-2055-4

Internet

http://link.springer.com/article/10.1186/s12967-019-2055-4

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