Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells

Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells

The mechanisms of transcriptional regulation underlying human primordial germ cell (PGC) differentiation are largely unknown. The transcriptional repressor Prdm1/Blimp-1 is known to play a critical role in controlling germ cell specification in mice. Here, we show that PRDM1 is expressed in developi...

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Bibliographic Details
Main Authors: I-Ying Lin, Feng-Lan Chiu, Chen-Hsiang Yeang, Hsin-Fu Chen, Ching-Yu Chuang, Shii-Yi Yang, Pei-Shan Hou, Nardnisa Sintupisut, Hong-Nerng Ho, Hung-Chih Kuo, Kuo-I Lin
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111300177X

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http://www.sciencedirect.com/science/article/pii/S221367111300177X

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