Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.

Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.

BACKGROUND: Oxygen free radicals induce lipid peroxidation (LPO) that damages and breaks polyunsaturated fatty acids in cell membranes. LPO-derived aldehydes and hydroxyalkenals react with DNA leading to the formation of etheno(ε)-bases including 1,N(6)-ethenoadenine (εA) and 3,N(4)-ethenocytosine (...

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Bibliographic Details
Main Authors: Paulina Prorok, Christine Saint-Pierre, Didier Gasparutto, Olga S Fedorova, Alexander A Ishchenko, Hervé Leh, Malcolm Buckle, Barbara Tudek, Murat Saparbaev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3522590?pdf=render

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http://europepmc.org/articles/PMC3522590?pdf=render

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