Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation

Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation

Summary: Ten-eleven translocation (Tet) enzymes are involved in DNA demethylation, important in regulating embryo development, stem cell pluripotency and tumorigenesis. Alterations of DNA methylation with age have been shown in various somatic cell types. We investigated whether Tet1 and Tet2 regula...

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Bibliographic Details
Main Authors: Guian Huang, Linlin Liu, Huasong Wang, Mo Gou, Peng Gong, Chenglei Tian, Wei Deng, Jiao Yang, Tian-Tian Zhou, Guo-Liang Xu, Lin Liu
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300924

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http://www.sciencedirect.com/science/article/pii/S2589004220300924

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