Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

Transcriptional memory allows certain genes to respond to previously experienced signals more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates transcriptional memory are poorly understood. Using HEK293F cells as a model system, we report that sustained TNF-α stimula...

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Bibliographic Details
Main Authors: Zuodong Zhao, Zhuqiang Zhang, Jingjing Li, Qiang Dong, Jun Xiong, Yingfeng Li, Mengying Lan, Gang Li, Bing Zhu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
transcriptional memory
TNF-α
TET enzymes
DNA methylation
DNA demethylation
CGRP
Online Access:https://elifesciences.org/articles/61965

Internet

https://elifesciences.org/articles/61965

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