The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians

The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening thrombotic microangiopathy caused by severe ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) deficiency, recurring in 30–50% of patients. The common human leukocyte antigen (HLA) varian...

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Bibliographic Details
Main Authors: Ilaria Mancini, Elisa Giacomini, Silvia Pontiggia, Andrea Artoni, Barbara Ferrari, Emanuela Pappalardo, Roberta Gualtierotti, Silvia Maria Trisolini, Saveria Capria, Luca Facchini, Katia Codeluppi, Erminia Rinaldi, Domenico Pastore, Simona Campus, Cinzia Caria, Aldo Caddori, Daniela Nicolosi, Gaetano Giuffrida, Vanessa Agostini, Umberto Roncarati, Clara Mannarella, Alberto Fragasso, Gian Marco Podda, Simone Birocchi, Anna Maria Cerbone, Antonella Tufano, Giuseppe Menna, Michele Pizzuti, Michela Ronchi, Alessandro De Fanti, Sergio Amarri, Marzia Defina, Monica Bocchia, Silvia Cerù, Salvatore Gattillo, Frits R. Rosendaal, Flora Peyvandi
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Journal of Clinical Medicine
Subjects:
ADAMTS13
autoimmune disease
genotyping
HLA
relapse
risk factor
Online Access:https://www.mdpi.com/2077-0383/9/10/3379

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https://www.mdpi.com/2077-0383/9/10/3379

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