Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.

Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.

Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ) signaling, leading to cell growth advantage. Halofuginone (HF), a low-molecular-weight alkaloid that modulates TGFβ signaling, was used to tr...

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Bibliographic Details
Main Authors: Lorena L de Figueiredo-Pontes, Patricia A Assis, Bárbara A A Santana-Lemos, Rafael H Jácomo, Ana Sílvia G Lima, Aglair B Garcia, Carolina H Thomé, Amélia G Araújo, Rodrigo A Panepucci, Marco A Zago, Arnon Nagler, Roberto P Falcão, Eduardo M Rego
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203897?pdf=render

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http://europepmc.org/articles/PMC3203897?pdf=render

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